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Duke-NUS - Metabolomics Facility

Duke-NUS Medical School
Research Facilities
Metabolomics Facility@DUKE-NUS

Metabolomics@DUKE-NUS

The Duke-NUS Metabolomics Facility (now Metabolomics @Duke-NUS) was established in 2012 with a goal to enhance the capabilities of scientists conducting metabolism-related research. Our targeted metabolomics platforms have been used to help provide new insights into the etiology of numerous diseases, as evidenced by the publication of high profile publications containing data derived from our facility.

Service

*Terms and Conditions of Service
*Sample Preparation Protocol

*Sample Labelling Template

Equipments

Contacts:

Jianhong Ching, Ph.D. | Assistant Professor, Cardiovascular and Metabolic Disorders

Tel: (65) 65856995/65856993 (lab) | Email: jianhong.ching@duke-nus.edu.sg

Kovalik, Jean-Paul, Ph.D. | Assistant Professor, Cardiovascular and Metabolic Disorders

Tel: (65) 6601 3144| Email: jean-paul.kovalik@duke-NUS.edu.sg

Location

Duke-NUS Medical School Singapore | National Heart Centre Singapore

|5 Hospital Drive #09-RDU-33 | Singapore 169609 |

Publication

1: de Carvalho LP, Tan SH, Ow GS, Tang Z, Ching J, Kovalik JP, Poh SC, Chin CT, Richards AM, Martinez EC, Troughton RW, Fong AY, Yan BP, Seneviratna A, Sorokin V, Summers SA, Kuznetsov VA, Chan MY. Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction. JACC Basic Transl Sci. 2018 May 30;3(2):163-175. doi: 10.1016/j.jacbts.2017.12.005. eCollection 2018 Apr

2: Liu JJ, Liu S, Gurung RL, Ching J, Kovalik JP, Tan TY, Lim SC. Urine tricarboxylic acid (TCA) cycle metabolites predict progressive chronic kidney disease in type 2 diabetes. J Clin Endocrinol Metab. 2018 Jul 27. doi: 10.1210/jc.2018-00947. [Epub ahead of print]

3: Koh AS, Gao F, Leng S, Kovalik JP, Zhao X, Tan RS, Fridianto KT, Ching J, Chua SJ, Yuan JM, Koh WP, Zhong L. Dissecting Clinical and Metabolomics Associations of Left Atrial Phasic Function by Cardiac Magnetic Resonance Feature Tracking. Sci Rep. 2018 May 25;8(1):8138. doi: 10.1038/s41598-018-26456-8.

4: 1: Tan HC, Yew TW, Chacko S, Tai ES, Kovalik JP, Ching J, Myo Thant S, Khoo CM. Comprehensive assessment of insulin resistance in non-obese Asian Indian and Chinese men. J Diabetes Investig. 2018 Nov; 9(6):1296-1303. doi: 10.1111/jdi.12844. Epub 2018 Apr 20. PubMed PMID: 29582571.

5: Lim WK, Davila S, Teo JX, Yang C, Pua CJ, Blöcker C, Lim JQ, Ching J, Yap JJL, Tan SY, Sahlén A, Chin CW, Teh BT, Rozen SG, Cook SA, Yeo KK, Tan P. Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research. PLoS Biol. 2018 Feb 27;16(2):e2004285. doi: 10.1371/journal.pbio.2004285. eCollection 2018 Feb.

6: Yao J, Kovalik JP, Lai OF, Lee PC, Eng A, Chan WH, Tham KW, Lim E, Bee YM, Tan HC. Comprehensive Assessment of the Effects of Sleeve Gastrectomy on Glucose, Lipid, and Amino Acid Metabolism in Asian Individuals with Morbid Obesity. Obes Surg. 2018 Sep 6. doi: 10.1007/s11695-018-3487-2. [Epub ahead of print]

7: Ramachandra CJA, Mehta A, Wong P, Ja KPMM, Fritsche-Danielson R, Bhat RV, Hausenloy DJ, Kovalik JP, Shim W. Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes. Int J Cardiol. 2018 Aug 24. pii: S0167-5273(18)34147-0. doi: 10.1016/j.ijcard.2018.08.069. [Epub ahead of print]