MD-PhD student publications by year

2020

Goh, Geraldine, Matae Ahn, Feng Zhu, Lim Beng Lee, Dahai Luo, Aaron T. Irving, and Lin-Fa Wang. "Complementary Regulation of Caspase-1 and Il-1β Reveals Additional Mechanisms of Dampened Inflammation in Bats." Proceedings of the National Academy of Sciences 117, no. 46 (2020): 28939-49. https://doi.org/10.1073/pnas.2003352117. https://www.pnas.org/content/pnas/117/46/28939.full.pdf.
Liu, Shiyang, Nathan Harmston, Trudy Lee Glaser, Yunka Wong, Zheng Zhong, Babita Madan, David M. Virshup, and Enrico Petretto. "Wnt-Regulated Lncrna Discovery Enhanced by in Vivo Identification and Crispri Functional Validation." Genome Medicine 12, no. 1 (2020/10/22 2020): 89. https://doi.org/10.1186/s13073-020-00788-5. https://doi.org/10.1186/s13073-020-00788-5.

2019

Masri, Mohamad Fadhli Bin, Chinmay Kumar Mantri, Abhay P. S. Rathore, and Ashley L. St. John. "Peripheral serotonin causes dengue-induced thrombocytopenia through 5HT₂ receptors." Blood (2019): blood-2018-08-869156. https://dx.doi.org/10.1182/blood-2018-08-869156.
Tan, T. Y.; Fibriansah, G.; Kostyuchenko, V. A.; Ng, T.-S.; Lim, X.-X.; Zhang, S.; Lim, X.-N.; Wang, J.; Shi, J.; Morais, M. C.; Corti, D.; Lok, S.-M., Capsid protein structure in Zika virus reveals the flavivirus assembly process. Nature Communications 2020, 11 (1), 895.
Grubman, A.; Chew, G.; Ouyang, J. F.; Sun, G.; Choo, X. Y.; McLean, C.; Simmons, R. K.; Buckberry, S.; Vargas-Landin, D. B.; Poppe, D.; Pflueger, J.; Lister, R.; Rackham, O. J. L.; Petretto, E.; Polo, J. M., A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation. Nature Neuroscience 2019, 22(12), 2087-2097.
Chong, J. L.; Low, L. L.; Chan, D. Y. L.; Shen, Y.; Thin, T. N.; Ong, M. E. H.; Matchar, D. B., Can we understand population healthcare needs using electronic medical records? Singapore Med J 2019.
Ahn, Matae, Danielle E. Anderson, Qian Zhang, Chee Wah Tan, Beng Lee Lim, Katarina Luko, Ming Wen, et al. "Dampened Nlrp3-Mediated Inflammation in Bats and Implications for a Special Viral Reservoir Host." Nature Microbiology 4, no. 5 (2019/05/01 2019): 789-99. https://doi.org/10.1038/s41564-019-0371-3. https://doi.org/10.1038/s41564-019-0371-3.

2018

Eric, D. Laing, H. Mendenhall Ian, Linster Martin, H. W. Low Dolyce, Chen Yihui, Yan Lianying, L. Sterling Spencer, Borthwick Sophie, Neves Erica Sena, S. L. Lim Julia, Skiles Maggie, P. Y. H. Lee Benjamin, Wang Lin-Fa, C. Broder Christopher, and J. D. Smith Gavin. 2018. "Serologic Evidence of Fruit Bat Exposure to Filoviruses, Singapore, 2011–2016." Emerging Infectious Disease journal 24 (1):122. doi: 10.3201/eid2401.170401.
Linster, Martin, Lien Anh Ha Do, Ngo Ngoc Quang Minh, Chen Yihui, Zhu Zhe, Tran Anh Tuan, Ha Manh Tuan, Yvonne C. F. Su, H. Rogier van Doorn, Mahesh Moorthy, and Gavin J. D. Smith. 2018. "Clinical and Molecular Epidemiology of Human Parainfluenza Viruses 1–4 in Children from Viet Nam." Scientific Reports 8 (1):6833. doi: 10.1038/s41598-018-24767-4.
Saputra, Elysia C., Lu Huang, Chen Yihui, and Lisa Tucker-Kellogg. 2018. "Combination Therapy and the Evolution of Resistance: The Theoretical Merits of Synergism and Antagonism in Cancer." Cancer Research. doi: 10.1158/0008-5472.can-17-1201.
Kwan YH, Fong W, How P, Wee HL, Leung YY, Phang JK, Tan CS, Malhotra R, Ostbye T, Thumboo J. The impact of axial spondyloarthritis on quality of life (QoL): A comparison with the impact of moderate to end-stage chronic kidney disease on QoL. 2018. Quality of Life Research. 27:2321-2327
Kwan YH, Fong W, Yong ST, Lui NL, Cheung YB, R Malhotra, T J Thumboo, T Ostbye. Validity and reliability of the health assessment questionnaire among patients with spondyloarthritis. International Journal of Rheumatic Diseases. 2018. 21(3):699-704.
Kwek SS, Watanabe S, Chan KR, Ong EZ, Tan HC, Ng WC, Nguyen MTX, Gan ES, Zhang SL, Chan KWK, Tan JH, Sessions OM, Manuel M, Pompon J, Chua C, Hazirah S, Tryggvason K, Vasudevan SG, Ooi EE. A systematic approach to the development of a safe live attenuated Zika vaccine. Nat Commun. 2018 Mar 12;9(1):1031.
Xie J, L. Y., Shen X, Goh G, Zhu Y, Cui J, Wang LF, Shi ZL, Zhou P, Dampened STING-Dependent Interferon Activation in Bats. . Cell Host Microbe 2018, 23 (3), 297-30

2017

Lau HY, Tang J, Casey PJ, Wang M. Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms. Oncogene. 2017. doi: 10.1038/onc.2016.508.
JL Chong, DB Matchar, Benefits of Population Segmentation Analysis for Developing Health Policy to Promote Patient-Centred Care, Annals of the Academy of Medicine Singapore, 2017, 287-289
Kwan YH, Fong W, Tan VIC, Lui NL, R Malhotra, T Ostbye, J Thumboo. A systematic review of quality of life domains and items relevant to patients with Spondyloarthritis. Seminars in Arthritis and Rheumatism. 2017. 47(2):175-182.
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Sandwiched between compassion and duty by Tan Chin Yee (Intake year 2017)12 September 2017 | Education, Upclose, Clinical Care and Innovation

2016

Hsieh JT, Ang BT, Ng YP, Allen JC, Nicolas KKK: Comparison of gender differences in intracerebral hemorrhage in a multi-ethnic asian population. PLoS One 2016;11:e0152945.
Tan RYC, Met-Domestici M, Zhou K, Guzman AB, Lim ST, Soo KC, Feeley TW, Ngeow J: Using quality improvement methods and time-driven activity-based costing to improve value-based cancer care delivery at a cancer genetics clinic. Journal of oncology practice / American Society of Clinical Oncology 2016;12:e320
Tan G, Zhou K, Tan CH, Matchar DB, Farid M, Quek R, Ngeow J: Cost effectiveness of universal hepatitis b virus screening in patients beginning chemotherapy for sarcomas or gi stromal tumors. Journal of Global Oncology 2016:JGO001669.
Y. Suzuki, S. Ng, C. Chua, W.Q. Leow, J. Chng, S.Y. Liu, K. Ramnarayanan, A. Gan, D.L. Ho, R. Ten, Y. Su, A. Lezhava, J.H. Lai, D. Koh, K.H. Lim, P. Tan, S.G. Rozen, I.B. Tan. “Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intramural heterogeneity in colorectal cancer” Molecular Oncology (2016)
JL Chong, Policy options for increasing the supply of transplantable kidneys in Singapore, Singapore Medical Journal, 2016, 530-532
Quek, D. Q., Nguyen, L. N., Fan, H., and Silver, D. L. Structural insights into the transport mechanism of the human sodium-dependent lysophosphatidylcholine transporter Mfsd2a. J Biol Chem (2016);291:9383-94
Wang, C., Ji, F., Hong, Z., Poh, J. S., Krishnan, R., Lee, J., Rekhi, G., Keefe, R. S., Adcock, R. A., Wood, S. J., Fornito, A., Pasternak, O., Chee, M. W. & Zhou, J. (2016). Disrupted salience network functional connectivity and white-matter microstructure in persons at risk for psychosis: findings from the LYRIKS study. Psychol Med, 1-13.
Wang, C., Ong, J. L., Patanaik, A., Zhou, J. & Chee, M. W. (2016). Spontaneous eyelid closures link vigilance fluctuation with fMRI dynamic connectivity states. Proc Natl Acad Sci U S A 113, 9653-8.
Goh KC, Tang CK, Norton DC, Gan ES, Tan HC, Sun B, Syenina A, Yousuf A, Ong XM, Kamaraj US, Cheung YB, Gubler DJ, Davidson A, St John AL, Sessions OM, Ooi EE. Molecular determinants of plaque size as an indicator of dengue virus attenuation. Sci Rep. 2016 May 17;6:26100
Kwan YH, Fong W, Yong ST, Lui NL, Cheung YB, R Malhotra, T Ostbye. J Thumboo. Validity and reliability of the Short Form 36 Health Surveys (SF-36) among patients with spondyloarthritis. Rheumatology International. 2016. 36(12):1759-1765.
Ahn, Matae, Jie Cui, Aaron T. Irving, and Lin-Fa Wang. "Unique Loss of the Pyhin Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing." Scientific Reports 6, no. 1 (2016/02/24 2016): 21722. https://doi.org/10.1038/srep21722. https://doi.org/10.1038/srep21722.

2015

Chee CY, Virshup DM, Madan B: The intestinal stem cell niche; in Turksen K (ed): Tissue-specific stem cell niche. Cham, Springer International Publishing, 2015, pp 135-162.

Eshaghi M, Sun G, Gruter A, Lim CL, Chee CY, Jung G, Jauch R, Wohland T, Chen SL: Rational structure-based design of bright gfp-based complexes with tunable dimerization. Angewandte Chemie 2015;127:14158.

Farah BL, Landau DJ, Sinha RA, Brooks ED, Wu Y, Fung SYS, Tanaka T, Hirayama M, Bay B-H, Koeberl DD: Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency. Journal of hepatology 2015.

Sinha RA, Singh BK, Zhou J, Wu Y, Farah BL, Ohba K, Lesmana R, Gooding J, Bay B-H, Yen PM: Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ros-ampk-ulk1 signaling. Autophagy 2015;11:1341-1357.

Goh VJ, Tan JS, Tan BC, Seow C, Ong W-Y, Lim YC, Sun L, Ghosh S, Silver DL: Postnatal deletion of fat storage-inducing transmembrane protein 2 (fit2/fitm2) causes lethal enteropathy. Journal of Biological Chemistry 2015;290:25686-25699.

Lei B, Wang H, Jeong S, Hsieh JT, Majeed M, Dawson H, Sheng H, Warner DS, James ML: Progesterone improves neurobehavioral outcome in models of intracerebral hemorrhage. Neuroendocrinology 2015.

Hsieh JT, Lei B, Sheng H, Venkatraman T, Lascola CD, Warner DS, James ML: Sex-specific effects of progesterone on early outcome of intracerebral hemorrhage. Neuroendocrinology 2015.

Joseph U, Linster M, Suzuki Y, Krauss S, Halpin RA, Vijaykrishna D, Fabrizio TP, Bestebroer TM, Maurer-Stroh S, Webby RJ, Group CHNW, members of the CHNWG: Adaptation of pandemic h2n2 influenza a viruses in humans. Journal of Virology 2015;89:2442-2447.

Deng Z-D, McClintock SM, Oey NE, Luber B, Lisanby SH: Neuromodulation for mood and memory: From the engineering bench to the patient bedside. Current opinion in neurobiology 2015;30:38-43.

Alakbarzade V, Hameed A, Quek DQ, Chioza BA, Baple EL, Cazenave-Gassiot A, Nguyen LN, Wenk MR, Ahmad AQ, Sreekantan-Nair A: A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter mfsd2a causes a non-lethal microcephaly syndrome. Nature genetics 2015;47:814-817.

Guemez-Gamboa A, Nguyen LN, Yang H, Zaki MS, Kara M, Ben-Omran T, Akizu N, Rosti RO, Rosti B, Scott E, Schroth J, Copeland B, Vaux KK, Cazenave-Gassiot A, Quek DQ, Wong BH, Tan BC, Wenk MR, Gunel M, Gabriel S, Chi NC, Silver DL, Gleeson JG: Inactivating mutations in mfsd2a, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Nature genetics 2015;47:809.

Zeitler EP, Pokorney SD, Zhou K, Lewis RK, Greenfield RA, Daubert JP, Matchar DB, Piccini JP: Cable externalization and electrical failure of the riata family of implantable cardioverter-defibrillator leads: A systematic review and meta-analysis. Heart Rhythm 2015;12:1233-1240.

Pokorney SD, Zhou K, Matchar DB, Love S, Zeitler EP, Lewis R, Piccini JP: Optimal management of riata leads with no known electrical abnormalities or externalization: A decision analysis: Riata decision analysis. Journal of Cardiovascular Electrophysiology 2015;26:184-191.

Ngeow J, Liu C, Zhou K, Frick KD, Matchar DB, Eng C: Detecting germline pten mutations among at-risk patients with cancer: An age- and sex-specific cost-effectiveness analysis. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015;33:2537.

2014

Kim H-J, Cho H, Alexander R, Patterson HC, Gu M, Lo KA, Xu D, Goh VJ, Nguyen LN, Chai X, Huang CX, Kovalik J-P, Ghosh S, Trajkovski M, Silver DL, Lodish H, Sun L: Micrornas are required for the feature maintenance and differentiation of brown adipocytes. Diabetes 2014;63:4045-4056.

Miranda DA, Kim J-H, Nguyen LN, Cheng W, Tan BC, Goh VJ, Tan JS, Yaligar J, KN BP, Velan SS: Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue. Journal of Biological Chemistry 2014;289:9560-9572.

Farah BL, Sinha RA, Wu Y, Singh BK, Zhou J, Bay B-H, Yen PM: Β-adrenergic agonist and antagonist regulation of autophagy in hepg2 cells, primary mouse hepatocytes, and mouse liver. PloS one 2014;9:e98155.

Farah BL, Madden L, Li S, Nance S, Bird A, Bursac N, Yen PM, Young SP, Koeberl DD: Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with pompe disease. The FASEB Journal 2014;28:2272-2280.

Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J, Ching J, Zhou J: Caffeine stimulates hepatic lipid metabolism by the autophagy‐lysosomal pathway in mice. Hepatology 2014;59:1366-1380.

Zhou J, Farah BL, Sinha RA, Wu Y, Singh BK, Bay B-H, Yang CS, Yen PM: Epigallocatechin-3-gallate (egcg), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. PloS one 2014;9:e87161.

Tan JS, Seow CJ, Goh VJ, Silver DL: Recent advances in understanding proteins involved in lipid droplet formation, growth and fusion. Journal of Genetics and Genomics 2014;41:251-259.

Lau HY, Ramanujulu PM, Guo D, Yang T, Wirawan M, Casey PJ, Go M-L, Wang M: An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo. Cancer biology & therapy 2014;15:1280-1291.

Ng KP, Manjeri A, Lee KL, Huang W, Tan SY, Chuah CTH, Poellinger L, Ong ST: Physiologic hypoxia promotes maintenance of cml stem cells despite effective bcr-abl1 inhibition. Blood 2014;123:3316-3326.

Wee CL, Teo S, Oey NE, Wright GD, VanDongen HM, VanDongen AM: Nuclear arc interacts with the histone acetyltransferase tip60 to modify h4k12 acetylation. eneuro 2014;1:ENEURO. 0019-0014.2014.

Oey NE, Leung HW, Ezhilarasan R, Zhou L, Beuerman RW, VanDongen HMA, VanDongen AMJ: A neuronal activity-dependent dual function chromatin-modifying complex regulates arc expression. eneuro 2014;2.

Soh SX, Lim JYS, Huang JW, Jiang N, Yeoh AEJ, Ong ST: Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a bim deletion polymorphism in pediatric acute lymphoblastic leukemia. PloS one 2014;9:e103435.

Jo J, Tan AT, Ussher JE, Sandalova E, Tang X-Z, Tan-Garcia A, To N, Hong M, Chia A, Gill US: Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver. PLoS Pathog 2014;10:e1004210.

Banu N, Chia A, Ho ZZ, Tan-Garcia A, Paravasivam K, Grotenbreg GM, Bertoletti A, Gehring AJ: Building and optimizing a virus-specific t cell receptor library for targeted immunotherapy in viral infections. Scientific reports 2014;4.

2013

Goh VJ, Silver DL: The lipid droplet as a potential therapeutic target in nafld: Seminars in liver disease, 2013, 33, pp 312-320.

2009

White CA, Oey NE, Emili A: Global quantitative proteomic profiling through 18o-labeling in combination with ms/ms spectra analysis. Journal of proteome research 2009;8:3653.

2008

Tan AT, Koh S, Goh VJ, Bertoletti A: Understanding the immunopathogenesis of chronic hepatitis b virus: An asian prospective. Journal of Gastroenterology and Hepatology 2008;23:833-843.

Tan AO, Chia A, Gehring AJ, Sastry KSR, Goh VJ, Bertoletti A, Seng GL, Loggi E, Andreone P, Boni C, Fisicaro P, Ferrari C, Brander C, Bihl F: Host ethnicity and virus genotype shape the hepatitis b virus-specific t-cell repertoire. 2008.